Pregabalin + Methylcobalamin + Nortriptyline Tablets

Pregabalin + Methylcobalamin + Nortriptyline Tablets come with the branding “NUROLONE-PLUS” and are used to treat neuropathic pain in patients with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that develops as a result of altered neural function caused by nerve injury, disease or disturbance in nerve communication. It ranges from spontaneous pain, unpleasant sensation or sensation, electric shock-like, hot or nail-like pain, and evoked pain.

Pregabalin + Methylcobalamin + Nortriptyline Tablets are a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a B vitamin that helps with the formation of the myelin sheath that insulates nerve fibres and generates new nerve tissues when destroyed.

Nortriptyline relieves pain by raising the levels of nerve transmitters such as serotonin and noradrenaline in the brain reducing the pain signals received. Pregabalin alleviates pain in a manner that slows down the messages of pain that are sent through the brain and along the spinal cord. All together; it is effective in the treatment of neuropathic pain.

Medical Benefits

• This medicine is used for the symptomatic treatment of peripheral neuropathy, post-herpetic neuralgias following spinal cord injury etc.
• Methylcobalamin helps to synthesize myelin, the material; that protects nerve fibers and recreates other damaged nerve tissues.
• Nortriptyline is an AED that alters nerve impulses by raising levels of serotonin and noradrenaline in the brain which will decrease the pain signals that reach the brain.
• Pregabalin helps to work by reducing the signals being sent between the brain and the spinal cord about pain.

Directions For Use

• Take Pregabalin + Methylcobalamin + Nortriptyline Tablets as your doctor has advised you with no changes whatsoever.
• Take with food especially a tablet, to prevent effects on the stomach.
• Swallow the tablet whole and never split it or chew on it.
• Please ensure that your child does not take this medication in any form.

Storage

• Keep the tablets out of reach of children to prevent incidental ingestion.
• Store the tablets in a cool, dry place away from heat, light, and moisture.
• Always keep the tablets in their original, tightly closed container.
• Make sure to securely close the container after each use to maintain the quality of the tablets.
• Avoid storing these tablets in places with high humidity.

Precautions

• It may interact with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), anti-convulsant medications (e.g. topiramate), and painkiller medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), etc.
• Pregabalin + Methylcobalamin + Nortriptyline Tablets may heighten the effects of alcohol therefore, patients are advised to abstain from alcohol while on the medication.
• Use this table with medical advice if experiencing an anticholinergic effect, cardiovascular disease, pheochromocytoma, after AMI therapy, cardiovascular disease, etc.
• It results in drowsiness, sleepiness and even impairment of vision, so do not drive or operate any machinery that needs full attention.
• Pregnant and breastfeeding mothers should consult doctor before taking this medication.

Side Effects

• Dry mouth
• Headache
• Constipation
• Diarrhoea
• Feeling sleepy, tired or dizzy

Frequently Asked Questions (FAQs)

Can I stop taking this tablet if I feel better?

No ,do not discontinue taking it without the doctor’s advice. Stopping this medicine suddenly may lead to withdrawal of symptoms. Complete the prescription of the doctor as advised.

Is it used for diabetic neuropathy?

Yes, this medicine is used for diabetic neuropathy which is nerve damage that results from high blood sugar and often affects the legs and feet.

Does it cause oedema?

Yes, it may lead to peripheral oedema which is swelling around the region of the hands and lower legs. To minimize inflammation, do not sit or stay for a long time on the feet and when sleeping put a pillow under the legs.

How to cope with dry mouth? 

A dry mouth is a possible side effect of this medicine. To manage it; drink water regularly, chew sugar-free gum or candy to stimulate saliva, limit caffeine intake and avoid smoking and use alcohol-free mouthwashes.